Anti-Inflammatory Raw Material Cms- 121 CAS 1353224-53-9 with Bulk Price
Model NO.
CMS-121
Colour
White
Grade Standard
Medicine Grade
Test Method
HPLC, Hnmr, LC-Ms, UV, IR
Application
Pharmaceutical Intermediates
Safety Precautions
Keep Away From Heat and Fire.
Transport Package
as Requirements
Specification
99%
Trademark
Shuer
Origin
Wuhan, China
HS Code
2933999099
Production Capacity
6 Ton/Tons Per Month
Reference Price
$ 5.75 - 6.39
Description
Product Description
Product name: CMS-121
CAS: 1353224-53-9
Molecular formula: C20H19NO3
Molecular weight: 321.37
Appearance: White Powder
Purity: 99.0%
Packge: 1kg,5kg,10KG or under requirement
Description: CMS-121 (CMS121) is a novel and potent fisetin-based derivative with anti-aging, neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities.
CMS121 is a substituted quin oline that has neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities. It maintains glutathione (GSH) levels in HT22 mouse hippocampal cells in vitro in the presence of glutamate, induces differentiation of PC12 cells, prevents LPS-induced N9 microglial activation by 82% in N9 microglia, and scavenges free radicals in a Trolox equivalent activity concentration (TEAC) assay. CMS121 protects against ischemia and oxytosis in phenotypic screens in HT22 cells in vitro with EC50 values of 7 and 200 nM for preventing iodoacetic acid- or glutamate-induced cell death, respectively. It is also renoprotective, decreasing kidney weight loss and decreasing the expression of TNF-α, caspase-1, and inducible nit ric oxi de synthase (iNOS) in a SAMP8 mouse model of chronic kidney disease associated with rapid aging when administered at a dose of 10 mg/kg per day starting at nine months of age.
We supply Overseas warehouses in Germany,USA,Poland,Holland,UK,Australia ,Canada ,Newzealand,Mexico and so on almost 100% success by courier local domestic shipping. Contact us for MSDS,COA,HPLC,Certificate. Thank you.
FAQ
Q1: Are you a manufacturer?
A: Yes, We manufacture bulk products in our factory located in Huangmei, Hubei, and produce small quantity and customer synthesis products in our lab located in Wuhan.
Q2: Do you have stock?
A: We understand most customers prefer stock, so we'll try to keep stock for most products. However, for some rare products, we won't keep stock and it needs time to synthesize.
Q3: What certificates and documents do you offer?
A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.
Q4: Why should I choose you?
A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over 5 years, in average.Strict quality control-comes form our sophisticated management system.
Professional and warm sales team-since we believe we can only win via our hard work in a competitive world
Quick response and excellent presale and after sale service-since we believe our customers deserve all the best service.
Q5: Can I get best price from you?
A: Of course. We don't chase excessive profits and always try tp give best offer. If you are good at bargaining, you can also enjoy fun of bargaining. Just don't make it too hard!
Q6: How should I pay?
A: We accept all kinds of payment ways. such as Credit card, Visa, T/T, West union, MoneyGram
CAS: 1353224-53-9
Molecular formula: C20H19NO3
Molecular weight: 321.37
Appearance: White Powder
Purity: 99.0%
Packge: 1kg,5kg,10KG or under requirement
Description: CMS-121 (CMS121) is a novel and potent fisetin-based derivative with anti-aging, neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities.
CMS121 is a substituted quin oline that has neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities. It maintains glutathione (GSH) levels in HT22 mouse hippocampal cells in vitro in the presence of glutamate, induces differentiation of PC12 cells, prevents LPS-induced N9 microglial activation by 82% in N9 microglia, and scavenges free radicals in a Trolox equivalent activity concentration (TEAC) assay. CMS121 protects against ischemia and oxytosis in phenotypic screens in HT22 cells in vitro with EC50 values of 7 and 200 nM for preventing iodoacetic acid- or glutamate-induced cell death, respectively. It is also renoprotective, decreasing kidney weight loss and decreasing the expression of TNF-α, caspase-1, and inducible nit ric oxi de synthase (iNOS) in a SAMP8 mouse model of chronic kidney disease associated with rapid aging when administered at a dose of 10 mg/kg per day starting at nine months of age.
We supply Overseas warehouses in Germany,USA,Poland,Holland,UK,Australia ,Canada ,Newzealand,Mexico and so on almost 100% success by courier local domestic shipping. Contact us for MSDS,COA,HPLC,Certificate. Thank you.
FAQ
Q1: Are you a manufacturer?
A: Yes, We manufacture bulk products in our factory located in Huangmei, Hubei, and produce small quantity and customer synthesis products in our lab located in Wuhan.
Q2: Do you have stock?
A: We understand most customers prefer stock, so we'll try to keep stock for most products. However, for some rare products, we won't keep stock and it needs time to synthesize.
Q3: What certificates and documents do you offer?
A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.
Q4: Why should I choose you?
A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over 5 years, in average.Strict quality control-comes form our sophisticated management system.
Professional and warm sales team-since we believe we can only win via our hard work in a competitive world
Quick response and excellent presale and after sale service-since we believe our customers deserve all the best service.
Q5: Can I get best price from you?
A: Of course. We don't chase excessive profits and always try tp give best offer. If you are good at bargaining, you can also enjoy fun of bargaining. Just don't make it too hard!
Q6: How should I pay?
A: We accept all kinds of payment ways. such as Credit card, Visa, T/T, West union, MoneyGram
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